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Figure 3 The progression-free survival curves for...

Figure 2 The overall survival curves for oligo-re...

Figure 2 (A) Kaplan–Meier survival curves stratif...

Figure 1 Overall survival and progression-free su...

Fig. 2 Kaplan–Meier curves for (a) overall surv...

Figure 6: The expression level of HJURP is a predictive factor for radiotherapy sensitivity. Kaplan-Meier survival curves for breast cancer patients according to radiotherapy treatment are presented. Part (a) shows the survival curves for disease-free survival, while (b) shows survival curves for overall survival. The P-values shown were obtained from a long-rank test.

Image Text (High Precision): HJURP High Low Moderate b radiotherapy survival time

Other Images from "The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer":


Figure 4 Validation of the association between HU...

Figure 5 Validation of the association between HJ...

Figure 3 The impact of HJURP expression and Ki67 ...

Figure 6 The expression level of HJURP is a predi...

Figure 8 Correlation between HJURP and CENPA in m...

Figure 2 Association of HJURP mRNA levels with cl...

Figure 7 The HJURP mRNA level in breast cancer ce...

Figure 1 HJURP is overexpressed in human breast c...

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Abstract

IntroductionHJURP (Holliday Junction Recognition Protein) is a newly discovered gene reported to function at centromeres and to interact with CENPA. However its role in tumor development remains largely unknown. The goal of this study was to investigate the clinical significance of HJURP in breast cancer and its correlation with radiotherapeutic outcome.MethodsWe measured HJURP expression level in human breast cancer cell lines and primary breast cancers by Western blot and/or by Affymetrix Microarray; and determined its associations with clinical variables using standard statistical methods. Validation was performed with the use of published microarray data. We assessed cell growth and apoptosis of breast cancer cells after radiation using high-content image analysis.ResultsHJURP was expressed at higher level in breast cancer than in normal breast tissue. HJURP mRNA levels were significantly associated with estrogen receptor (ER), progesterone receptor (PR), Scarff-Bloom-Richardson (SBR) grade, age and Ki67 proliferation indices, but not with pathologic stage, ERBB2, tumor size, or lymph node status. Higher HJURP mRNA levels significantly decreased disease-free and overall survival. HJURP mRNA levels predicted the prognosis better than Ki67 proliferation indices. In a multivariate Cox proportional-hazard regression, including clinical variables as covariates, HJURP mRNA levels remained an independent prognostic factor for disease-free and overall survival. In addition HJURP mRNA levels were an independent prognostic factor over molecular subtypes (normal like, luminal, Erbb2 and basal). Poor clinical outcomes among patients with high HJURP expression were validated in five additional breast cancer cohorts. Furthermore, the patients with high HJURP levels were much more sensitive to radiotherapy. In vitro studies in breast cancer cell lines showed that cells with high HJURP levels were more sensitive to radiation treatment and had a higher rate of apoptosis than those with low levels. Knock down of HJURP in human breast cancer cells using shRNA reduced the sensitivity to radiation treatment. HJURP mRNA levels were significantly correlated with CENPA mRNA levels.ConclusionsHJURP mRNA level is a prognostic factor for disease-free and overall survival in patients with breast cancer and is a predictive biomarker for sensitivity to radiotherapy.


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