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Figure 1: The Kaplan-Meier curves comparing overall survival (OS) for patients at high risk of nodal involvement, as defined in text receiving whole pelvic radiotherapy (WPRT) combined with neoadjuvant androgen deprivation therapy (N-ADT) or prostate radiotherapy only (PORT), (P = .13).

Image Text (High Precision): months overall radiotherapy survival

Other Images from "Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer":


Figure 1 The Kaplan-Meier curves comparing overal...

Figure 2 The Kaplan-Meier curves comparing cause ...

Figure 3 The Kaplan-Meier curves comparing bioche...

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Abstract

Aim. To study whether use of neoadjuvant androgen deprivation therapy (N-ADT) combined with whole pelvic radiotherapy (WPRT) for high-risk prostate cancer patients was associated with survival benefit over prostate radiotherapy (PORT) only. Material and Methods. Between 1999 and 2004, 162 high-risk prostate cancer patients were treated with radiotherapy combined with long-term androgen deprivation therapy (L-ADT). Patients were prospectively assigned into two groups: A (N-ADT + WPRT + L-ADT) n = 70 pts, B (PORT + L-ADT) n = 92 pts. Results. The 5-year actuarial overall survival (OS) rates were 89% for A and 78% for B (P = .13). The 5-year actuarial cause specific survival (CSS) rates were A = 90% and B = 79% (P = .01). Biochemical progression-free survival (bPFS) rates were 52% versus 40% (P = .07), for groups A and B, respectively. Conclusions. The WPRT combined with N-ADT compared to PORT for high-risk patients resulted in improvement in CSS and bPFS; however no OS benefit was observed.


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